List of Articles (2018-2019)


  1. “Mortality and morbidity in patients receiving encainide, flecainide, or placebo” (CAST). N Engl J Med. 1991 Mar 21;324(12):781-8. [post – Week 1] [free full text]
  2. “Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure” (SOLVD). N Engl J Med. 1991 Aug 1;325(5):293-302. [post – Week 6] [free full text]
  3. “Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).” Lancet. 1994 Nov 19;344(8934):1383-9. [post – Week 17] [free full text]
  4. “The effect of spironolactone on morbidity and mortality in patients with severe heart failure” (RALES). N Engl J Med. 1999 Sep 2;341(10):709-17. [post – Week 22] [free full text]
  5. “Effect of carvedilol on survival in severe chronic heart failure.” (COPERNICUS). N Engl J Med. 2001 May 31;344(22):1651-8. [post – Week 19] [free full text]
  6. “Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation” (CHADS2). JAMA. 2001 Jun 13;285(22):2864-70. [post – Week 15] [free full text]
  7. “Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).” JAMA. 2002 Dec 18;288(23):2981-97. [post – Week 25] [free full text]
  8. “A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation” (AFFIRM). N Engl J Med. 2002 Dec 5;347(23):1825-33. [post – Week 11] [free full text]
  9. “Optimal Medical Therapy with or without PCI for Stable Coronary Disease” (COURAGE). N Engl J Med. 2007 Apr 12;356(15):1503-16. [post – Week 45] [free full text]
  10. “A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey.” Chest. 2010 Nov;138(5):1093-100. [post – Week 36] [free full text]
  11. “Apixaban versus warfarin in patients with atrial fibrillation” (ARISTOTLE). N Engl J Med. 2011 Sep 15;365(11):981-92. [post – Week 32] [free full text]
  12. “Strategies for multivessel revascularization in patients with diabetes” (FREEDOM). N Engl J Med. 2012 Dec 20;367(25):2375-84. [post – Week 43] [free full text]
  13. “Angiotensin-neprilysin inhibition versus enalapril in heart failure” (PARADIGM-HF). N Engl J Med. 2014 Sep 11;371(11):993-1004. [post – Week 49] [free full text]


  1. “Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial” (VERT). JAMA. 1999 Oct 13;282(14):1344-52. [post – Week 50] [free full text]
  2. “Effects of Intensive Glucose Lowering in Type 2 Diabetes” (ACCORD). N Engl J Med. 2008 Jun 12;358(24):2545-59. [post – Week 46] [free full text]
  3. “Intensive versus Conventional Glucose Control in Critically Ill Patients” (NICE-SUGAR). N Engl J Med 2009; 360:1283-1297. [post – Week 9] [free full text]


  1. “Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis.” N Engl J Med. 1999 Aug 5;341(6):403-9. [post – Week 2] [free full text]
  2. “Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.” N Engl J Med. 2000 Aug 3;343(5):310-6. [post – Week 20] [free full text]
  3. “A model to predict survival in patients with end-stage liver disease” (MELD score). Hepatology. 2001 Feb;33(2):464-70. [post – Week 16] [free full text]
  4. “Rifaximin treatment in hepatic encephalopathy.” N Engl J Med. 2010 Mar25;362(12):1071-81. [post – Week 51] [free full text]
  5. “Early use of TIPS in patients with cirrhosis and variceal bleeding.” N Engl J Med. 2010 Jun 24;362(25):2370-9. [post – Week 31] [free full text]
  6. “Transfusion strategies for acute upper gastrointestinal bleeding.” N Engl J Med. 2013 Jan 3;368(1):11-21. [post – Week 41] [free full text]
  7. “Prednisolone or pentoxifylline for alcoholic hepatitis” (STOPAH). N Engl J Med. 2015 Apr 23;372(17):1619-28. [post – Week 47] [free full text]

Hematology / Oncology

  1. “A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group” (TRICC). N Engl J Med. 1999 Feb 11;340(6):409-17. [post – Week 23] [free full text]
  2. “Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer” (CLOT). N Engl J Med. 2003 Jul 10;349(2):146-53. [post – Week 10] [free full text]
  3. “Mortality results from a randomized prostate-cancer screening trial” (PLCO). N Engl J Med. 2009 Mar 26;360(13):1310-9. [post- Week 34] [free full text]
  4. “Early palliative care for patients with metastatic non-small-cell lung cancer.” N Engl J Med. 2010 Aug 19;363(8):733-42. [post – Week 18] [free full text]
  5. “Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening” (NLST). N Engl J Med. 2011 Aug 4;365(5):395-409. [post – Week 44] [free full text]
  6. “Oral rivaroxaban for the treatment of symptomatic pulmonary embolism.” (EINSTEIN-PE). N Engl J Med. 2012 Apr 5;366(14):1287-97. [post – Week 21] [free full text]

Infectious Disease

  1. “Dexamethasone in Adults With Bacterial Meningitis.” N Engl J Med 2002; 347:1549-1556. [post – Week 4] [free full text]
  2. “Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study” (CURB-65). Thorax. 2003 May;58(5):377-82. [post – Week 14] [free full text]
  3. “Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial” (PneumA). JAMA. 2003 Nov 19;290(19):2588-98. [post – Week 29] [free full text]
  4. “Effect of early versus deferred antiretroviral therapy for HIV on survival.” N Engl J Med. 2009 Apr 30;360(18):1815-26. [post – Week 38] [free full text]
  5. “Duodenal infusion of donor feces for recurrent Clostridium difficile.” N Engl J Med. 2013 Jan 31;368(5):407-15. [post – Week 52] [free full text]


  1. “Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.” N Engl J Med. 1999 Dec 2;341(23):1725-30. [post – Week 27] [free full text]
  2. “Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes” (IDNT). N Engl J Med. 2001 Sep 20;345(12):851-60. [post – Week 5] [free full text]
  3. “Correction of anemia with epoetin alfa in chronic kidney disease.” (CHOIR). N Engl J Med. 2006 Nov 16;355(20):2085-98. [post – Week 3] [free full text]
  4. “Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status.” J Am Soc Nephrol. 2009 Sep;20(9):2075-84. [post – Week 30] [free full text]
  5. “A controlled trial of renal denervation for resistant hypertension.” (SYMPLICITY HTN-3). N Engl J Med. 2014 Apr 10;370(15):1393-401. [post – Week 48] [free full text]

Pulmonary/Critical Care

  1. “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome” (ARDSNet). N Engl J Med. 2000 May 4;342(18):1301-8. [post – Week 7] [free full text]
  2. “Early goal-directed therapy in the treatment of severe sepsis and septic shock.” (Rivers trial). N Engl J Med. 2001 Nov 8;345(19):1368-77. [post – Week 12] [free full text]
  3. “Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.” N Engl J Med. 2002 Feb 21;346(8):549-56. [post – Week 26] [free full text]
  4. “Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial.” JAMA. 2006 Jul 5;296(1):56-63. [post – Week 33] [free full text]
  5. “Hydrocortisone therapy for patients with septic shock” (CORTICUS). N Engl J Med. 2008 Jan 10;358(2):111-24. [post – Week 35] [free full text]
  6. “Prone positioning in severe acute respiratory distress syndrome.” (PROSEVA). N Engl J Med. 2013 Jun 6;368(23):2159-68. [post – Week 40] [free full text]
  7. “The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)” (SEPSIS-3). JAMA. 2016 Feb 23;315(8):801-10. [post – Week 13] [free full text]
  8. “A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.” N Engl J Med. 2016 Oct 27;375(17):1617-1627. (LOTT). [post – Week 37] [free full text]


  1. “Clinical and Radiographic Outcomes of Four Different Treatment Strategies in Patients with Early Rheumatoid Arthritis (the BeSt Study).” Arthritis & Rheumatism. 2005 Nov;52(11):3381-3390. [post – Week 42] [free full text]


  1. “Fever of unexplained origin: report on 100 cases.” Medicine (Baltimore). 1961 Feb;40:1-30. [post – Week 8] [free full text]
  2. “Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial.” Arch Intern Med. 2002 May 27;162(10):1117-21. [post – Week 28] [free full text]
  3. “Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.” Lancet. 2008 May 31;371(9627):1839-47. [post – Week 39] [free full text]
  4. “The Oregon Experiment – Effects of Medicaid on Clinical Outcomes.” N Engl J Med. 2013 May 2;368(18):1713-22. [post – Week 24] [free full text]